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非天然氨基酸及其它砌块合成
β- Amyloid (1-40)
名称
β- Amyloid (1-40)
分子结构式
CAS号
131438-79-4
分子式
C194H295N53O58S
分子量
4329.82
作用靶点
Amyloid-β
序列号
Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val
短序列号
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
国际标识符代码
FEWOUVRMGWFWIH-UHFFFAOYSA-N
溶解度
50mg/mL
水中溶解度
50mg/mL
纯度
≥95%
引用文献
[1]. Shoji M, et al. Cerebrospinal fluid Abeta40 and Abeta42: natural course and clinical usefulness. Front Biosci. 2002 Apr 1;7:d997-1006. [2]. Cleary J, et al. Beta-amyloid(1-40) effects on behavior and memory. Brain Res. 1995 Jun 5;682(1-2):69-74. [3]. Olariu A, et al. Memory impairment induced by chronic intracerebroventricular infusion of beta-amyloid (1-40) involves downregulation of protein kinase C. Brain Res. 2002 Dec 13;957(2):278-86.
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β-Amyloid (1-40) is a primary protein in plaques found in the brains of patients with Alzheimer's disease.