CEA -HLA DR7(Peptide Sequence: EIIYPNASLLIQN) 默迪夫生物

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CEA -HLA DR7(Peptide Sequence: EIIYPNASLLIQN)

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名称 CEA -HLA DR7(Peptide Sequence: EIIYPNASLLIQN)	分子结构式
正常/肿瘤 gut carcinoma(RNA)
人类白细胞抗原 DR7(用于人类白细胞抗原 II类)
HLA% 25
肽序列 EIIYPNASLLIQN
位置 99-111
Lymphocyte Stimulation peptide
NCBI Gene SummaryNCBI This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
GeneCards Summary CEACAM5 (CEA Cell Adhesion Molecule 5) is a Protein Coding gene. Diseases associated with CEACAM5 include Lung Non-Small Cell Carcinoma and Bile Duct Cancer. Among its related pathways are Metabolism of proteins and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and GPI anchor binding. An important paralog of this gene is CEACAM1.
UniProtKB SwissProt Summary Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:2803308, 10910050, 10864933). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050). ( CEAM5_HUMAN,P06731 ) (Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. (CEAM5_HUMAN,P06731)
引用文献 [1].Crosti M, Longhi R, Consogno G, Melloni G, Zannini P, Protti MP. Identification of novel subdominant epitopes on the carcinoembryonic antigen recognized by CD4+ T cells of lung cancer patients. J Immunol. 2006 Apr 15, 176(8):5093-9. (PMID: 16585607).

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