BCLX (L) -HLA A2(Peptide Sequence: YLNDHLEPWI) 默迪夫生物

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BCLX (L) -HLA A2(Peptide Sequence: YLNDHLEPWI)

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名称 BCLX (L) -HLA A2(Peptide Sequence: YLNDHLEPWI)	分子结构式
正常/肿瘤 ubiquitous (low level)(RNA)
人类白细胞抗原 A2
HLA% 44
肽序列 YLNDHLEPWI
位置 173-182
Lymphocyte Stimulation peptide
NCBI Gene SummaryNCBI The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015]
GeneCards Summary BCL2L1 (BCL2 Like 1) is a Protein Coding gene. Diseases associated with BCL2L1 include Absolute Glaucoma and B-Cell Lymphoma. Among its related pathways are MAPK family signaling cascades and Nuclear events mediated by NFE2L2. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is BCL2.
UniProtKB SwissProt Summary Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. ( B2CL1_HUMAN,Q07817 ) Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785). ( B2CL1_HUMAN,Q07817 )
引用文献 [1].Sørensen RB1, Hadrup SR, Køllgaard T, Svane IM, thor Straten P, Andersen MH. Efficient tumor cell lysis mediated by a Bcl-X(L) specific T cell clone isolated from a breast cancer patient. Cancer Immunol Immunother. 2007 Apr, 56(4):527-33. (PMID: 16850344).

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