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非天然氨基酸及其它砌块合成
Ganirelix
名称
Ganirelix
分子结构式
CAS号
123246-29-7
分子式
C80H113ClN18O13
分子量
1570.32
作用靶点
GnRH Receptor
序列号
Ac-D-2Nal-D-Phe(4-Cl)-D-3Pal-Ser-Tyr-D-{Har(Et,Et)}-Leu-{Har(Et,Et)}-Pro-D-Ala-NH2
短序列号
Ac-{D-2Nal}-{D-Phe(4-Cl)}-{D-3Pal}-SY-{D-Har(Et,Et)}-L-{Har(Et,Et)}-P-{D-Ala}-NH2
国际标识符代码
GJNXBNATEDXMAK-PFLSVRRQSA-N
纯度
95%
引用文献
[1]. Gillies PS, et al. Ganirelix. Drugs. 2000 Jan;59(1):107-11; discussion 112-3. [2]. Russo A, et al. Effects of the gonadotropin-releasing hormone antagonist ganirelix on normal micturition and prostaglandin E(2)-induced detrusor overactivity in conscious female rats. Eur Urol. 2011 May;59(5):868-74.
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Ganirelix is a competitive and selective gonadotropin releasing hormone (GnRH) antagonist. Ganirelix prevents endogenous GnRH from inducing luteinising hormone (LH) and follicle stimulating hormone relea