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非天然氨基酸及其它砌块合成
Satralizumab Linker
名称
Satralizumab Linker
分子结构式
CAS号
1491917-83-9
分子式
C76H104N12O24S
分子量
1601.8
作用靶点
Antibody-Drug Conjugates (ADCs) TROP2
国际标识符代码
ULRUOUDIQPERIJ-PQURJYPBSA-N
水中溶解度
25 mg/mL
纯度
≥95%
引用文献
[1]. Cardillo TM, et al. Sacituzumab Govitecan (IMMU-132), an Anti-Trop-2/SN-38 Antibody-Drug Conjugate: Characterization and Efficacy in Pancreatic, Gastric, and Other Cancers. Bioconjug Chem. 2015 May 20;26(5):919-31. [2]. Goldenberg DM, Cardillo TM, Govindan SV, Rossi EA, Sharkey RM. Trop-2 is a novel target for solid cancer therapy with sacituzumab govitecan (IMMU-132), an antibody-drug conjugate (ADC) [published correction appears in Oncotarget. 2020 Mar 10;11(10):942]. Oncotarget. 2015;6(26):22496-22512.
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Sacituzumab govitecan  is an antibody-drug conjugate (ADC) targeting Trop-2 for delivery of SN-38. Sacituzumab govitecan shows anticancer activity.