Calcitonin (a polypeptide composed of 32 amino acids) is one of the preferred drugs for the treatment of osteoporosis, and the advantages of calcitonin are that it inhibits osteoclast activity, reduces the number of osteoclasts, inhibits bone resorption, and reduces bone turnover, while calcitonin has a central nervous system analgesic effect and can relieve bone pain. The disadvantage of calcitonin is that its half-life is too short and it needs to be administered by injection once a day. In addition, a significant proportion of patients with calcitonin develop nausea, abdominal pain, swollen hands, and rubella at the injection site.