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非天然氨基酸及其它砌块合成
DBCO-acid
名称
DBCO-acid
分子结构式
CAS号
1353016-70-2
分子式
C19H15NO3
分子量
305.33
作用靶点
ADC Linker
国际标识符代码
NDLOVDOICXITOK-UHFFFAOYSA-N
溶解度
100 mg/mL
纯度
≥95%
引用文献
[1]. Zimmerman ES, et al. Production of site-specific antibody-drug conjugates using optimized non-natural amino acids in a cell-free expression system. Bioconjug Chem. 2014 Feb 19;25(2):351-61.
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DBCO-acid is a cleavable ADC linker used in the synthesis of ADC linker DBCO-NHS ester (HY-115524 and HY-115545), and agent-linker conjugates DBCO-PEG-MMAE (HY-111012 and HY-126690)[1]. DBCO-acid is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.