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非天然氨基酸及其它砌块合成
Neuro Peptide Y(13-36)(porcine)
名称
Neuro Peptide Y(13-36)(porcine)
分子结构式
CAS号
367518-31-8
分子式
C135H209N41O36
分子量
2982.36
作用靶点
Neuropeptide Y Receptor
序列号
Pro-Ala-Glu-Asp-Leu-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2
短序列号
PAEDLARYYSALRHYINLITRQRY-NH2
国际标识符代码
HEALDAASUSTTPJ-QGTLAHJGSA-N
纯度
95%
引用文献
[1]. [Leu31-Pro34] neuropeptide Y identifies a subtype of 125I-labeled peptide YY binding sites in the rat brain. [2]. Centrally truncated and stabilized porcine neuropeptide Y analogs: design, synthesis, and mouse brain receptor binding. [3]. Effects of galanin message-associated peptide and neuropeptide Y against various non-albicans Candida strains.
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Neuropeptide Y 13-36 (porcine) is a selective neuropeptide Y2 receptor agonist (Ki = 0.18 nM). It mimics the effects of NPY at presynaptic receptors in vas deferens.

This fragment is able to compete with the intact NPY for essentially all binding sites in rat brain. However, it is less potent than the native peptide in its NPY-receptor binding affinity.