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非天然氨基酸及其它砌块合成
Obestatin, rat, mouse
名称
Obestatin, rat, mouse
分子结构式
CAS号
869705-22-6
分子式
C114H174N34O31
分子量
2516.87
作用靶点
GHSR
序列号
Phe-Asn-Ala-Pro-Phe-Asp-Val-Gly-Ile-Lys-Leu-Ser-Gly-Ala-Gln-Tyr-Gln-Gln-His-Gly-Arg-Ala-Leu-NH2
短序列号
FNAPFDVGIKLSGAQYQQHGRAL-NH2
国际标识符代码
FNAPFDVGIKLSGAQYQQHGRAL-NH2
纯度
≥95%
引用文献
[1]. Azadeh Toosi, et al. Obestatin Improve Spatial Memory Impairment in a Rat Model of Fetal Alcohol Spectrum Disorders via Inhibiting Apoptosis and Neuroinflammation. Neuropeptides. 2019 Apr;74:88-94. [2]. Science. 2005 Nov 11;310(5750):996-9. doi: 10.1126/science.1117255.
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Obestatin(rat), encoded by the Ghrelin gene, is a cpeptide, comprised of 23 amino acids. Obestatin(rat) suppresses food intake, inhibits jejunal contraction, and decreases body-weight gain. Obestatin is an endogenous ligand of G-protein coupled receptor 39 (GPR39). Obestatin(rat) has anti-inflammatory, anti-myocardial infarction and antioxidant activities.