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目录肽(按字母分类)
非天然氨基酸及其它砌块合成
Z-LVG-CHN2
名称
Z-LVG-CHN2
分子结构式
CAS号
119670-30-3
分子式
C22H31N5O5
分子量
445.51
作用靶点
Cathepsin/HSV/SARS-CoV
序列号
Z-Leu-Val-Gly-diazomethylketone
短序列号
Z-LVG-DMK
国际标识符代码
KRMMQWXJLDORCJ-OALUTQOASA-N
溶解度
100 mg/mL
纯度
95%
引用文献
[1]. R L Mellgren, et al. Inhibition of growth of human TE2 and C-33A cells by the cell-permeant calpain inhibitor benzyloxycarbonyl-Leu-Leu-Tyr diazomethyl ketone. Exp Cell Res. 1994 Nov;215(1):164-71. [2]. L Björck, et al. Cystatin C, a human proteinase inhibitor, blocks replication of herpes simplex virus. J Virol [3]. Laura Riva, et al.A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals. bioRxiv. 2020 Apr 17;2020.04.16.044016.
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The diazomethyl ketone Z-LVG-CHN2 mimics part of the human cysteine proteinase-binding center, has been shown to be an irreversible inhibitor of this proteinase. The compound was also tested for antiviral activity against herpes simplex virus type 1 (HSV) and found to block the HSV replication.

Irreversible inhibitor of streptopain.