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非天然氨基酸及其它砌块合成
Tyr-CRF (ovine)
名称
Tyr-CRF (ovine)
分子结构式
CAS号
83930-34-1
分子式
C214H348N60O65S
分子量
4833.59
作用靶点
CRFR
序列号
Tyr-Ser-Gln-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Thr-Lys-Ala-Asp-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Leu-Asp-Ile-Ala-NH2
短序列号
YSQEPPISLDLTFHLLREVLEMTKADQLAQQAHSNRKLLDIA-NH2
国际标识符代码
JJLVQUXEFPEDOD-PPMZARRPSA-N
纯度
≥95%
引用文献
[1]. Schulte HM, et al. Metabolic clearance rate and plasma half-life of radioiodinated corticotropin releasing factor in a primate. J Clin Endocrinol Metab. 1982 Nov;55(5):1023-5. [2]. Rebaudo R, et al. Electrophysiological effects of sustained delivery of CRF and its receptor agonists in hippocampal slices. Brain Res. 2001 Dec 13;922(1):112-7.
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Tyr-CRF (ovine) is a corticotropin releasing factor/hormone isolated from ovine. CRF is a hypothalamic hormone, stimulates the release of adrenocorticotropic hormone (ACTH) and of β-endorphin.