Dynorphin A (1-17), (Prodynorphin 209-225), Porcine CAS:80448-90-4 序列:YGGFLRRIRPKLKWDNQ 默迪夫生物

Dynorphin A is an endogenous opioid peptide involved in inhibitory neurotransmission in the central nervous system (CNS). Dynorphin A is a highy potent kappa opioid receptor (KOR) agonist, and is also an agonist for other opioid receptors, such as mu (MOR) and delta (DOR). Dynorphin A can induce neuronal death, and can be used in the research of neurological disease.

名称 Dynorphin A (1-17), (Prodynorphin 209-225), Porcine	分子结构式
CAS号 80448-90-4
分子量 2147.53
分子式 C99H155N31O23
短序列号 YGGFLRRIRPKLKWDNQ
序列号 Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln
国际标识符代码 JMNJYGMAUMANNW-FIXZTSJVSA-N
纯度 ≥95%
作用靶点 Opioid Receptor; Apoptosis; Caspase; Endogenous Metabolite
DMSO溶解度 100mg/mL
水中溶解度 ≥100mg/mL
引用文献 [1]. Zhang, et al.Dynorphin A as a Potential Endogenous Ligand for Four Members of the Opioid Receptor Gene Family. J Pharmacol Exp Ther. 1998 Jul;286(1):136-41. [2]. Aruna Sharma, et al. Monoclonal antibodies as novel neurotherapeutic agents in CNS injury and repair. Int Rev Neurobiol. 2012;102:23-45. [3]. I. N. SINGH, et al. Dynorphin A (1–17) induces apoptosis in striatal neurons in vitro through AMPA/kainate receptor-mediated cytochrome c release and caspase-3 activation. Neuroscience. 2003;122(4):1013-23. [4]. K F Hauser, et al. Dynorphin A (1-13) neurotoxicity in vitro: opioid and non-opioid mechanisms in mouse spinal cord neurons. Exp Neurol. 1999 Dec;160(2):361-75. [5]. B J Van de Heijning, et al. Dynorphin-A and vasopressin release in the rat: a structure-activity study. Neuropeptides. 1994 Jun;26(6):371-8. [6]. Takayoshi Mamiya, et al. Dynorphin a (1-13) alleviated stress-induced behavioral impairments in mice. Biol Pharm Bull. 2014;37(8):1269-73.