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Teplow's Amyloid β-Protein (1-42) (scrambled II)

名称
Teplow's Amyloid β-Protein (1-42) (scrambled II)
分子结构式
CAS号
1987844-92-7
分子量
4514.04
分子式
C203H311N55O60S1
短序列号
YHAGVDKEVVFDEGAGAEHGLAQKIVRGFGVSDVSMIHINLF
序列号
Tyr-His-Ala-Gly-Val-Asp-Lys-Glu-Val-Val-Phe-Asp-Glu-Gly-Ala-Gly-Ala-Glu-His-Gly-Leu-Ala-Gln-Lys-Ile-Val-Arg-Gly-Phe-Gly-Val-Ser-Asp-Val-Ser-Met-Ile-His-Ile-Asn-Leu-Phe
纯度
95%
作用靶点
Amyloid-β
引用文献
[1].Design, Characterization, and Use of a Novel Amyloid β-Protein Control for Assembly, Neurotoxicity, and Gene Expression Studies.
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This peptide is a specifically designed negative control in studies with Abeta42. It is "scrambled", which means it contains the same amino acids as Abeta42, but in different order. Referring to studies by Yamin and coworkers, Teplow's Amyloid β-Protein (1-42) does not show a number of phenomena regularly observed with Abeta42 (fibril formation, oligomerization, toxicity to neurons) and furthermore has a relatively flat hydropathy profile, which can be an advantage in several studies, for example in order to avoid unspecific interaction with the cell membrane.